The clinical manifestations of acute hemolytic anemia are divided into extravascular hemolytic anemia manifestations and intravascular hemolytic anemia manifestations according to the site of hemolysis, as follows: 1. Acute extravascular hemolytic anemia: mostly manifested as anemia, jaundice, splenomegaly and other symptoms; 2. Acute intravascular hemolytic anemia: mostly manifested as chills, high fever, low back pain, deepening of urine color with soy sauce-like or thick tea-like changes, and also coagulation Acute hemoglobin decline. In general, acute hemolytic anemia and intravascular hemolysis are more common, mostly caused by blood transfusion of incompatible blood types, severe infection, immune factors, etc. Patients may have anemia, jaundice and other changes in mild cases, or severe bleeding with altered consciousness and coagulation dysfunction. After the occurrence of acute hemolytic anemia, appropriate treatment should be given according to different causes. In case of acute attack of anemia due to autoimmune hemolysis, glucocorticoid treatment can be generally considered. After the acute phase is treated with intravenous glucocorticosteroids, after the acute phase is stabilized, the treatment can be gradually switched to oral glucocorticosteroids, and the dosage will be gradually reduced after 1 month of maintenance. In the case of patients with acute autoimmune hemolytic anemia for which glucocorticoid therapy is ineffective, they can also be treated with splenectomy, or second-line therapy such as immunosuppressants.