A high activated partial thromboplastin time indicates that the patient’s actual clotting time is prolonged relative to the normal clotting time, often suggesting coagulation factor deficiency or abnormal activation of coagulation factors. Usually prolonged clotting time is mainly associated with hemophilia, fibrin deficiency, disseminated intravascular coagulation, liver disease, and drug effects: 1. Hemophilia: a group of genetic bleeding disorders with severe coagulation dysfunction, resulting in prolonged prothrombin time due to congenital coagulation factor deficiency, such as coagulation factor VIII or IX; 2. Fibrin deficiency: fibrin deficiency, as well as severe prothrombinogen and reduced coagulation factors V and X can lead to the occurrence of obstructive jaundice and neonatal bleeding disorder, which in turn leads to prolonged prothrombin time; 3, diffuse intravascular coagulation: a systemic intravascular microthrombosis occurring on the basis of a variety of serious diseases, leading to thrombohemorrhagic syndrome, resulting in increased consumption of coagulation factors in the body, which in turn leads to prolonged activated partial thromboplastin time; 4, liver disease: because the liver in The liver plays an important role in the hematopoietic system and coagulation function, when there is abnormal liver function disease, it will lead to a reduction in coagulation factors and prolongation of the activated partial thromboplastin time; 5, the role of drugs: the use of anticoagulant drugs, such as low-molecular heparin, and thrombolytic drugs, etc., will lead to a high activated partial thromboplastin time, causing the risk of bleeding, the need for regular testing of coagulation time in the process of medication.