Hemophilia VIII refers to coagulation factor VIII, which is an injectable drug and should not be taken orally. It is explained below in terms of indications and contraindications, and adverse reactions. 1. Coagulation factor VIII is used for the treatment of congenital coagulation factor VIII deficiency (hemophilia A), vascular hemophilia, acquired coagulation factor VIII deficiency, and hypofibrinogenemia. Use after consultation and evaluation by a medical professional. The dosage and frequency of injections are usually determined by the patient’s bleeding volume and weight. 2. Coagulation factor VIII is effective in the treatment of hemophilia, but there are some adverse reactions, such as chills, fever, hives and other allergic reactions, and may even lead to serious conditions such as a drop in blood pressure and shock. Therefore, it is necessary to pay more attention when using the drug. In addition, those who are allergic to the ingredients of the drug should avoid using it. The use of specific drugs should be carried out under the guidance of a physician.