The diagnosis of hemophilia requires a check of coagulation factor activity and a medical history, with specific criteria varying according to hemophilia subtypes. 1. Hemophilia A or B: Men with a clear positive family history, onset at an early age, clinical manifestations such as spontaneous bleeding or a history of more than one bleed from minor trauma, hematoma formation, and joint bleeding. Prolonged activated partial thromboplastin time (APTT) and abnormal coagulation factor VIII activity are considered as hemophilia A, and abnormal coagulation factor IX activity is considered as hemophilia B. 2. Acquired hemophilia: mostly spontaneous bleeding, but no family history, history of repeated bleeding since childhood, clinical manifestations are basically the same as above. The clinical manifestations are basically the same as above. Laboratory tests show prolongation of APTT and positive specific antibodies to auto-coagulation factor VIII or factor IV. 3. Vascular hemophilia: with or without family history, tendency to skin and mucous membrane bleeding since childhood, prolonged bleeding time, defective platelet adhesion and aggregation function, and decreased vWF antigen activity in laboratory tests. If there is unexplained spontaneous bleeding, it is recommended to consult a doctor in time to find out the cause and standardize the treatment under the doctor’s guidance so as not to delay the condition.