Positive antinuclear antibodies in pediatric uveitis need to be treated for both uveitis and autoimmune diseases.
1. Uveitis: For uveitis, the inflammation should be controlled as early as possible to enlarge the pupil and prevent pupil adhesion.
(1) Control of inflammation: topical glucocorticosteroids, including: cortisone acetate, prednisone acetate eye drops or ointment for topical use, prednisolone acetate injection for subconjunctival injection and so on.
(2) Dilating the pupil: applying pupil-dilating drugs to relieve ciliary muscle spasm and sphincter spasm. Commonly used pupil-dilating agents include: atropine, scopolamine, postmatropium and so on.
2. Autoimmune diseases: positive antinuclear antibodies are often seen in autoimmune diseases, which can cause uveitis. It is usually seen in rheumatic arthropathy, multiple sclerosis and Behcet’s disease. Symptomatic treatment should be given for these diseases.
(1) Use of non-steroidal anti-inflammatory drugs (NSAIDs): mainly for patients with joint swelling and pain.
(2) Colchicine: effective for joint lesions, erythema nodosum.
(3) Topical glucocorticoid orally: combined with oral ulcers and uveitis, it can improve the symptoms.
For children with uveitis combined with positive antinuclear antibodies, they should seek medical treatment as early as possible to determine the cause of the disease and then formulate an individualized treatment plan for the disease.