Whether hepatitis B e antigen 27 is serious or not should be judged in combination with other test results, such as liver function, alpha-fetoprotein, abdominal ultrasound results, etc. If these test results are normal, then it is generally not serious, if they are not normal, then it is serious. 1. Liver function: it can directly reflect the basic condition of the liver, suggesting whether the reserve synthesis function of the liver is affected, if the liver function is damaged, it is usually necessary to take medication under the guidance of the doctor. 2. Alpha-fetoprotein: for chronic hepatitis B, especially for male patients over 30 years old and those with family history of liver cancer, the examination of alpha-fetoprotein is particularly important, which is of great value for the early diagnosis of primary liver cancer, and if the alpha-fetoprotein is positive, it is suspected to be primary liver cancer. 3. Abdominal ultrasound: it can directly check the size, shape, cirrhosis and diameter of portal vein of the liver to check whether the patient has cirrhosis, portal hypertension and other complications. It is suggested that patients should actively go to the hospital for consultation, do relevant examinations and timely treatment under the guidance of doctors.