The common causes of itchy red bumps on the ankles and wrists are eczema, insect bite dermatitis, and drug rash. 1. Eczema: can appear in any part of the body, mostly symmetrical distribution. It is an inflammatory skin disease caused by internal and external stimuli. Especially in the acute stage, there will be red papules of grain size, with obvious exudation, mostly accompanied by itching. 2. Insect bite dermatitis: it is an inflammatory reaction caused by insect bites. If the ankle is bitten by an insect, there will be red bumps on the ankle, especially itchy performance. The general reaction to insect bites can subside in 7 to 10 days. 3. Drug rash: If the ankle applied some ointment allergy, resulting in local skin allergic reaction, will also cause red bumps on the ankle, especially itchy. Severe drug rash will also appear chills, high fever and other systemic manifestations. As you can see, there are many reasons for the itchy red bumps on the ankles and wrists, and it is recommended to go to the regular hospital in time.