Elevated CA153 caused by various diseases usually will not decrease on its own if not actively treated, but the occasional high level found by physical examination may return to normal. CA153 is the most important specific marker for breast cancer, which can be used to assist in the diagnosis of breast cancer, and can also be used to monitor tumor recurrence and metastasis. Elevated CA153 may also be associated with malignant tumors such as lung cancer, colon cancer and liver cancer. If the patient does not take any measures, the value usually does not decrease on its own. Mild elevations of CA153 may also occur in non-malignant diseases of the liver, gastrointestinal tract, lungs, breast, ovaries, etc., and may return to normal after active treatment. In addition, mild elevations occasionally found on physical examination may return to normal on their own if there is no other discomfort. Patients with elevated CA153 should go to the hospital in time, and take appropriate treatment after clarifying the cause of the disease, so as to avoid delaying the condition.