Interlobular pleural multiple nodules may be bacterial infection, pleural tuberculosis and tumor, etc. Depending on the different etiology, it can be treated with medications such as levofloxacin and rifampicin, or surgery, radiotherapy and chemotherapy. 1. Bacterial infection: bacterial infection can cause multiple inflammatory nodules in pleura, which can be treated with antibacterial drugs such as levofloxacin and cefaclor. 2. Pleural tuberculosis: when tuberculosis spreads to the pleura, it can also lead to the formation of multiple caseous nodules in the pleura, which can be treated with anti-tuberculosis drugs such as isoniazid, rifampicin and pyrazinamide. 3. Tumor: primary tumor or metastatic tumor of pleura can form multiple tumor nodules in pleura, which can be treated by surgical resection, radiotherapy and chemotherapy and other comprehensive treatments. Interleaf pleural multiple nodules should go to the hospital in time, complete the examination, and give targeted treatment after clarifying the cause of the disease according to the doctor’s instructions.