Systemic lupus erythematosus is hereditary. Systemic lupus erythematosus is a connective tissue disease with multi-systemic involvement, which can invade all organs of the body. The onset of the disease is closely related to genetic factors, therefore, SLE has a certain degree of heritability. According to studies, the risk of SLE in first-degree relatives of SLE is eight times higher than that in the general population. SLE is mainly associated with HLA-DR2, which is polygenic and multisite, but not 100% dominant, and people with a family history of SLE have a higher chance of developing the disease than the general population. If someone in the family has SLE, patients need to pay more attention to the symptoms such as fatigue, fever, pteroid erythema on the face, etc., they should go to the rheumatology and immunology department of regular hospitals for detailed consultation and follow the doctor’s advice.