Itchy hands in contact with paint is usually caused by acute urticaria, contact dermatitis and other diseases, different diseases, different treatments, can be applied locally by drugs (such as glycerine lotion, hydrocortisone cream, etc.), oral medication (such as cetirizine, phenylephrine, etc.), etc., to relieve the symptoms. 1. Acute urticaria: Hand contact with paint may cause acute urticaria, resulting in patients with itchy hands, and itchy parts will soon appear, the itchy area around the more around the red halo, can be fused into a piece, orange peel-like appearance. The paint should be removed, and follow the doctor’s instructions oral cetirizine, diclofenac tadalafil and other antihistamines to control the condition, if the condition can not be effectively controlled, oral glucocorticosteroids as appropriate, such as prednisone, etc., the condition of the serious patients, accompanied by laryngeal edema, patients should be immediately consult a doctor or call an emergency number. 2. Contact dermatitis: hand contact with paint is easy to trigger contact dermatitis, leading to localized erythema, papules, blisters, etc., and can be accompanied by itching, swelling and pain. The paint should be washed off immediately with water, if there is no oozing, you can follow the doctor’s instructions to apply local glycerine lotion; if there is oozing, you can use 3% boric acid solution cold wet compresses. And can follow the doctor’s instructions to apply glucocorticoid drugs, such as hydrocortisone cream, dexamethasone acetate cream, etc., if there is an infection, you can apply mupirocin. For severe itching, oral antihistamines such as loratadine and cetirizine can be taken to relieve symptoms. In addition, itchy hands in contact with paint may also be caused by other factors, it is recommended to go to the hospital in a timely manner, to clarify the cause of the disease, and then follow the doctor’s instructions for treatment.