Late-stage gallbladder cancer not wanting to eat can be treated by general treatment, drug treatment and surgery. 1. General treatment: Eating should be light and small amount of meals can be taken. 2. Drug treatment: if diet cannot meet nutritional requirements, nutrients such as fat milk, amino acid and albumin can be considered. Gastric motility drugs (such as domperidone, mosapride, etc.) can be used appropriately to promote gastrointestinal peristalsis, as well as drugs to protect gastric mucosa, such as aluminum hydroxide, can also be used to protect gastric mucosa. 3. Surgical treatment: If obstruction of biliary tract or gastrointestinal tract causes not wanting to eat, surgical treatment such as gastrointestinal stent implantation, biliary stent implantation, palliative biliary-intestinal anastomosis can be considered to restore the function of gastrointestinal tract. When gallbladder cancer is in advanced stage, one should ensure sleep, pay attention to dietary regulation, have regular rechecks, and seek medical treatment promptly if discomfort. The above medicines should be used under doctor’s guidance, avoid purchasing and using by oneself.