Thermoregulatory disorders are fevers resulting from abnormalities in the thermoregulatory center due to central nervous system pathology. Thermoregulatory disorders are rare among the various causes of fever, and their manifestations and management are different from those of common infectious and other causes of fever. Therefore, when determining the central fever, we should first exclude all kinds of infectious, pharmacological and other causes of fever. A moderate increase in body temperature that is difficult to explain cannot be easily considered as central fever. It is commonly associated with hypothermia, phenothiazine antipsychotic intoxication, craniopharyngioma, anxiety disorders, hypothalamic disorders, etc. Central nervous system dysfunction affects vegetative nerve function and causes abnormal cardiovascular system function The etiology may be related to physical, neurological, surrounding environment, and genetic factors. Some patients are often in a state of depression and anxiety and are more likely to suffer from thermoregulation disorders. How to check for thermoregulation disorders? 1.Commonly used examination methods are general status examination and body temperature measurement. 2, high body temperature, more than 39 degrees. 3.High trunk temperature and low extremity temperature. 4.Body temperature is elevated, but there is no corresponding change in heart rate. 5.Poor response to antipyretic and analgesic drugs, physical cooling is effective. 6, central hyperthermia or infectious fever can be distinguished from the following two points: first, whether the fever is accompanied by sweating, central hyperthermia is not sweating, while general infectious fever is accompanied by sweating, and second, the response to drugs, central hyperthermia to antipyretic and analgesic drugs and hormone therapy is ineffective, while the fever caused by infection has a good antipyretic effect.