The depression in the middle of the waist may be a normal physiologic curvature, and this condition is normal. It may also be caused by scoliosis, trauma, developmental abnormalities and other pathologic factors. 1. Normal lumbar spine is curved forward, there will be a normal depression in the back of the physiological curvature, will be manifested as lumbar depression, is a normal physiological curvature, will not cause discomfort, is not in need of treatment. 2. Scoliosis: it may be due to the abnormal curvature of a section of the lumbar vertebrae, resulting in the appearance of the waist has been sunken into the situation. In this case, it is necessary to correct it through support, exercise, and if necessary, surgery to restore the normal position of the spine. 3. Local trauma: patients with old fractures, fractures with dislocation, etc. may have local deformity after treatment, which may lead to lumbar depression. CT and MRI can be used to determine whether bone injury has occurred, and the presence of bone injury may require surgical treatment. Oral medication such as Celecoxib and Loxoprofen sodium can be taken for treatment. 4. Developmental abnormalities: such as congenital malformations, excessive anterior protrusion, lumbar curvature is too large, usually easy to be found in the appearance. This situation requires surgery for correction. To summarize, the middle of the waist depression should be timely medical treatment, specific or to be diagnosed after the cause of the disease, follow the doctor’s instructions for treatment.