The first three negative items in hepatitis B two half pairs refer to hepatitis B surface antigen, hepatitis B surface antibody and hepatitis B e antigen are negative, while the last two positive items refer to hepatitis B e antibody and hepatitis B core antibody are positive, which usually indicate the recovery period of acute hepatitis B virus infection or previous infection with hepatitis B virus, and it is necessary to choose the treatments such as regular check-ups and medication according to the different situations. 1. Recovering from acute hepatitis B virus infection: Usually, the treatment should be decided according to the results of quantitative DNA of hepatitis B virus, i.e. HBV-DNA, liver function and other tests. If the test results are basically normal, regular review and follow-up can be chosen; if the test results are abnormal, it is necessary to use liver-protecting drugs, mainly polyene phosphatidylcholine, reduced glutathione, etc., and antiviral drugs such as entecavir, lamivudine, etc., which should be used under the guidance of professional physicians. 2. Previously infected with hepatitis B virus: If you have been infected with hepatitis B virus in the past and have recovered, the hepatitis B virus has been cleared from your body, and the hepatitis B half-pair test will show the above results. Generally there is no need for special treatment, only regular review, if necessary, can be injected with hepatitis B vaccine to increase the antibody of hepatitis B virus in the body. If there is any obvious abnormality in hepatitis B two-half tests, you should consult a doctor in time to identify the cause of the disease and target treatment, so as not to cause liver function damage.