Common spots include freckles, chloasma, age spots (i.e. seborrheic keratosis) and so on. The causes of these spots are different, and the reasons why they are difficult to eliminate are also different, as follows: 1. Freckles: the cause of freckles is unknown, mostly considered to be related to genetic factors and sunlight factors. It is usually difficult to be cured and mostly occurs on the face. Daily, it should avoid strong light radiation and other factors, and if necessary, it can be treated with laser therapy according to doctor’s prescription. 2. Chloasma: the cause of chloasma is unknown, which may be related to heredity, sun exposure, hormone level, etc. The reason why it is difficult to remove is that the cause and pathogenesis of the disease are not clear, and although there are many treatments for the disease, their efficacy varies, and on the other hand, the recurrence rate of the disease is higher, so it is very difficult to eliminate it. 3. Age spots: Age spots, also known as seborrheic keratosis, is a kind of common epidermal benign tumor, which can be treated with laser therapy to achieve better efficacy, but since the disease may be related to skin aging, heredity, gene mutation, etc., there is a possibility of recurrence of the disease, which is difficult to eliminate. In addition, natural moles may appear as “spots”, such as Mongolian spots, nevus of Ota, etc., which mostly occur in infants and young children. The cause of these diseases is usually unknown, and may be related to embryonic development or genetic mutation. Some of the diseases may gradually fade away with age, but most of them are difficult to fade away by themselves. It is recommended that patients with skin spots should go to regular hospitals in time, and standardize the treatment after clarifying the target. In daily life, we should pay attention to sun protection, list diet, appropriate intake of vitamin C-rich food, which can remove free radicals in the body, effective antioxidant, and at the same time, we should stay up less late to relieve the pressure of the body.