Acute urticaria in 3-year-old children should first avoid contact with allergenic substances and seek medical attention in time to be treated with antihistamine drugs under the guidance of a doctor. Acute urticaria in 3-year-old children should first actively search for allergens and avoid contact. For urticaria induced by infectious factors, the primary infection should be actively treated. Meanwhile, antihistamines such as cetirizine hydrochloride drops and loratadine syrup can be used as prescribed by the doctor. If the condition is serious with shock and respiratory distress, 0.1% epinephrine can be injected subcutaneously or intramuscularly. 3-year-old children with acute urticaria, parents should take their children to the hospital in a timely manner, and actively cooperate with the doctor’s treatment, the specific use of drugs need to follow the doctor’s instructions, not blindly self-administered drugs.