The best time for minimally invasive surgery for lung nodules is mainly based on the growth size of the nodule and the degree of malignancy. 1. Growth size: Surgery is needed to treat lung nodules when the diameter of the nodule, especially ground-glass nodules mixed with solid nodules, is greater than one centimeter, and the likelihood of malignancy increases as the diameter of the nodule increases. Surgery is required for the first discovery of lung nodules or for monitoring of lung nodules with a diameter greater than one centimeter. 2. The degree of benignity and malignancy: in the process of lung nodule monitoring or the first discovery of lung nodules, the border is not clear, the internal echoes are irregular, there are burrs or lobules around, and there are pleural pulling and other malignant features, then you need to carry out timely surgical treatment, and in the process of monitoring, the lung nodule increases rapidly in a short period of time, and you need to have surgical treatment as well. For the best time to operate on lung nodules, it is recommended that you can consult a thoracic surgeon in a regular hospital.