Patients with eye pain after staying up late, may be caused by excessive eye fatigue, patients can be treated through the development of good eye habits, medication and other ways to relieve eye discomfort. For a long time to stay up late, excessive eye pain, the main consideration is excessive eye fatigue caused by patients need to restore normal enough rest and sleep, in addition to massage and hot compresses to promote blood circulation in the eyes, relieve eye discomfort. If the patient’s eye discomfort is obvious, the patient can follow the doctor’s instructions to use sodium vitrate eye drops and other drugs to moisturize the eye surface, relieve eye discomfort. In addition to the above, for the eye swelling and soreness at night, patients should also be alert to glaucoma and other pathological conditions. It is recommended that patients who experience significant eye pain after staying up late should seek prompt medical attention to assess their condition and follow doctor’s instructions for treatment.