Bifidobacterium tetragonum tablets and norfloxacin should not be taken at the same time, and generally need to be separated by at least 2 hours or more. Bifidobacterium tetragonum tablets is a kind of intestinal probiotic preparation, mainly composed of Bifidobacterium bifidum, Lactobacillus, Enterococcus and other ingredients, which is mainly used in the clinic for the treatment of diarrhea, constipation, functional dyspepsia and other disorders associated with intestinal flora dysregulation. Norfloxacin is a fluoroquinolone antibacterial drug with broad-spectrum antimicrobial effect, which has better killing effect on bacteria of genus Citrobacter, Escherichia coli, Klebsiella, Shigella, Vibrio and so on. Norfloxacin is commonly used clinically for the treatment of urinary tract infections, prostatitis, intestinal infections and other Salmonella infections caused by sensitive bacteria. Bifidobacterium tetragonum tablets is a kind of intestinal probiotic preparation, while norfloxacin is an antibacterial drug, the two are taken at the same time, will affect the efficacy of Bifidobacterium tetragonum tablets, therefore, it is generally not recommended that Bifidobacterium tetragonum tablets and norfloxacin be taken at the same time. If the condition requires, an interval of more than 2 hours is generally recommended. When taking Bifidobacterium tetrapunctate tablets and Norfloxacin, it is recommended to consult your doctor in advance and take them in strict accordance with the doctor’s instructions, rather than self-medicating, so as not to delay or even aggravate the condition.