Elevated blood pressure after coffee enema is considered to be caused by caffeine in coffee. Caffeine contained in coffee is a commonly used psychoactive substance with diuretic and sodium effects, and the rectal mucosa rapidly absorbs the caffeine in coffee after coffee enema, leading to an acute elevation of caffeine in the organism. Acute elevation of caffeine in the blood excites the sympathetic nerves, leading to elevated blood pressure. In addition, an article published in 2012 in the Chinese Journal of Food and Health concluded that coffee should be used as a beverage and is not recommended to be used as an enema, and that coffee as an enema does not have the effect of detoxifying the body. If blood pressure rises after a coffee enema, you need to seek medical attention in a timely manner, not self-medication to avoid adverse consequences.