Bone cancer (clinically known as osteosarcoma) generally needs to be judged more accurately by combining patients’ clinical symptoms, medical history, blood biochemistry examination, X-ray examination, CT examination and pathological examination. In the early stage, patients with osteosarcoma may have localized pain, joint swelling, bone deformity and other manifestations. As the condition progresses, there will be pathological fracture, muscle atrophy, wasting, weakness and other symptoms. It is also necessary to see whether the patient has a history of other benign or malignant tumors, and the specific location of osteosarcoma should also be examined, which can be clarified by X-ray and CT. In addition, osteosarcoma should be identified with other benign bone tumors. In general, it can be initially identified by symptoms, blood biochemistry examination and imaging examination, and biopsy should be performed to obtain pathological results to judge if necessary. A single symptom and examination result can not confirm the diagnosis completely, and it is necessary to make a comprehensive judgment to be more accurate.