The better drugs for treating pyelonephritis are quinolones such as oxfloxacin, etc. In addition, penicillins such as amoxicillin and cephalosporins such as cefuroxime are also available for treating pyelonephritis, which need to be selected according to the patient’s condition and drug sensitivity test. 1. Oxyfloxacin: mainly used for the treatment of retrograde infection of kidney and urinary tract caused by bacillus, adverse reactions include gastrointestinal reactions, such as abdominal pain, diarrhea, nausea, vomiting, etc. It is forbidden for those who have a history of allergy to quinolone antimicrobials, pregnant women and lactating women, and children. 2. Amoxicillin: used for upper and lower respiratory tract infections, genitourinary tract infections, skin and soft tissue infections, acute simple gonorrhea, etc., adverse reactions such as nausea, vomiting, diarrhea, rash, etc., penicillin allergy is contraindicated. 3. Cefuroxime: used for the treatment of pyelonephritis and other infections caused by sensitive bacteria. Adverse reactions include abdominal pain, diarrhea, nausea, vomiting, loss of appetite, mouth ulcers, etc. Cefuroxime is contraindicated in patients who are allergic to cephalosporin antibiotics. It is recommended that patients with pyelonephritis should go to the hospital in time, complete the examination under the guidance of the doctor, and follow the doctor’s instructions for symptomatic treatment, and should not blindly use drugs without authorization.