There is usually no significant correlation between high uric acid and mouth ulcers, which are mostly associated with infections, oral mucosal injuries, nutritional deficiencies, certain diseases and other factors. Uric acid is the metabolite of purine in the body, and high uric acid concentration will form hyperuricemia. Early on, there may be no obvious symptoms, with the development of the disease, gouty arthritis, gout stone, etc., the clinical manifestations are mainly red, swollen and hot pain in the joints. Usually, high uric acid is not the cause of mouth ulcers. Mouth ulcers are small, shallow defects or erosions in the oral mucosa, and their causes are complex. Bacterial infections such as Helicobacter pylori infection are associated with mouth ulcers. Oral ulcers can also result when the oral mucosa is mechanically damaged and temperature stimulated. Recurrent oral ulcers can result when there is a deficiency of nutrients such as B vitamins and folic acid. Certain diseases such as leukemia and systemic lupus erythematosus can cause oral ulcers. It is recommended that patients with high uric acid and mouth ulcers should consult rheumatology, stomatology and other related departments in a timely manner and follow the doctor’s instructions for treatment.