High hepatitis B virus means that hepatitis B virus replication is active and requires antiviral treatment, commonly used drugs include interferon and nucleoside antiviral drugs. 1. Interferon: it has the functions of anti-virus, anti-tumor, immune regulation and inhibition of cell proliferation, and can be used for the treatment of Hepatitis B Triple III, the common adverse reactions are fever, fatigue, headache and myalgia, etc., and a small number of patients may have elevated aminotransferase and creatinine, and should be used with caution in allergy, especially in those who are allergic to antibiotics. 2. Nucleoside antiviral drugs: such as entecavir, tenofovir, lamivudine and adefovir, of which entecavir and tenofovir are the first-line drugs. Common adverse effects of nucleoside antivirals include nausea, vomiting, headache, diarrhea, abdominal pain, and rash, and should be used with caution in pregnant and lactating women. In addition, the use of these drugs carries certain risks, and patients are advised to seek medical advice from their specialists.