Acute lymphoblastic leukemia blood routine abnormalities are mostly reflected in the white blood cells, red blood cells, platelets, etc. Most of them are elevated white blood cells, lowered platelets and red blood cells, and elevated proportion of abnormal naïve cells. Acute lymphoblastic leukemia mainly originates from B or T lineage lymphoid progenitor cells. Leukemia cells proliferate and aggregate abnormally in the bone marrow, inhibiting normal hematopoiesis and leading to anemia, thrombocytopenia and neutropenia. About 90% of patients have obvious hematological abnormalities, most of them have abnormally high white blood cell counts, while a few patients have reduced white blood cell counts; anemia is manifested by reduced red blood cell counts and lowered hemoglobin volume, which are mostly orthocytotic and normochromic; it is often accompanied by a reduction in platelet counts; in addition to this, an elevated percentage of naïve cells is also seen. If physical examination reveals abnormal blood counts and acute lymphoblastic leukemia is suspected, it is recommended to actively improve the examination to clarify the diagnosis and actively standardize the treatment.