Vulvar leukoplakia, i.e. hypopigmented vulva, is a gynecological disease mainly characterized by vulvar itching and hypopigmentation of the vulvar skin, which is mostly related to heredity, low immunity, low hormone level, inflammation stimulation, etc. Clinically, it is usually treated by topical ointment, laser and surgery, and the therapeutic effect varies from person to person. For patients with milder symptoms, medications can be applied to the vulva. Hydrocortisone ointment is a kind of hormonal topical ointment, which can relieve the symptoms of vulvar itching, but most patients can not adhere to the use of topical ointment, it is difficult to achieve curative effect, and the long-term use of the skin will cause skin irritation, and may appear hyperpigmentation, skin atrophy and other adverse reactions. Laser is a more common therapeutic technique nowadays, which can inhibit the inflammatory reaction and reduce the itching through the photothermal effect of laser, and the required treatment time is shorter with a better prognosis. However, after laser treatment, the skin is more fragile, if you do not pay attention to local hygiene, it is easy to cause infection and aggravate the symptoms. If medication and physical therapy are ineffective, atypical hyperplasia of the vulvar skin occurs, or vulvar cancer, surgical treatment is needed to remove the diseased tissue in order to achieve the therapeutic goal. To summarize, for patients with vulvar hypopigmentation disease, they should first do examination to clarify the cause of the disease and the extent of the disease, and then choose a reasonable way of treatment under the guidance of the doctor, which is able to achieve the therapeutic purpose.