There is no fastest way to reduce pathological jaundice in newborns, and phototherapy, medication and blood exchange can be used to reduce jaundice according to the specific conditions of newborns. 1. phototherapy: neonatal pathological jaundice is caused by abnormally high bilirubin level in the body, blue light irradiation is the most commonly used way to reduce jaundice, which can promote the excretion of non-conjugated bilirubin, and newborns should be replenished with fluids during the phototherapy period, and the bilirubin level and temperature should be monitored at any time. 2. medication: small-dose saline enema can be used to promote intestinal peristalsis to increase excretion and reduce the absorption of bilirubin, as well as injections of immunoglobulin, supplemental albumin, phenobarbital injections and other drugs, which can effectively bind free bilirubin and thus reduce the level of bilirubin. 3. Blood exchange therapy: For children who are ineffective in phototherapy and medication, blood exchange therapy can be used according to the actual situation to exchange bilirubin out of the body. Therefore, when a newborn baby develops pathological jaundice, a suitable way to eliminate jaundice can be chosen according to the actual situation of the baby and under the advice of the doctor.