Liver failure coma develops into hepatic encephalopathy, and the cure rate of hepatic encephalopathy cannot be judged, which mainly depends on the degree of hepatocyte failure and treatment methods. The cure rate is relatively high in patients with fair hepatocellular function and metabolism or with portal vein-corporeal circulation shunt, and the causative factors are clear and easy to be removed. The cure rate varies with different treatments. Generally, the cure rate of comprehensive internal medicine treatment is 20%-40%, and the cure rate of early and middle stage liver failure can reach more than 60% with the application of artificial liver treatment. The cure rate is lower for those with poor hepatocyte function, accompanied by obvious jaundice, ascites, hypoalbuminemia, and complicated by serious infection, upper gastrointestinal hemorrhage, water-electrolyte and acid-base balance disorders, and hepatorenal syndrome. Liver failure coma should be treated as early as possible, do not delay the time of treatment.