Guillain-Barré syndrome is a class of immune-mediated peripheral neuropathies that develop when the body’s immune system attacks the peripheral nerves, resulting in impairment of peripheral nerve conduction. Symptoms of Guillain-Barré syndrome will manifest as symmetrical muscle weakness in the limbs, which in most patients progresses from the lower limbs of both limbs to the trunk muscles, getting progressively worse. Some patients may also experience weakness of the face or muscles supporting respiration, circulation, digestion, and in severe cases, weakness of the cervical and respiratory muscles, and the patient may feel dyspnea. When these symptoms occur, prompt medical attention is required. Guillain-Barré Syndrome requires timely access to the hospital, the doctor will conduct laboratory tests, pathological examinations, etc., to clarify the severity of the disease, and then choose the appropriate way of treatment, one of the most effective treatment is plasma replacement within the immunotherapy.