Whether gastrointestinal mesothelioma can be cured or not, generally early gastrointestinal mesothelioma can be completely cured with surgical treatment, while advanced mesothelioma, especially with extensive metastasis, cannot be completely cured. Early stage gastrointestinal mesothelioma can be treated, most of them are found through physical examination, the biological behavior is inert, the progress is very slow, and the changes can be observed through regular follow-up gastroscopy. Early detection of gastrointestinal mesenchymal tumors can be removed by surgical laparoscopic resection, need to ensure that the surgical resection is clean, there is no tumor cell residue, postoperative pathological grading, give the appropriate chemotherapeutic drugs such as imatinib and other therapies, generally can achieve a complete cure. For advanced gastrointestinal mesenchymal stromal tumors, it is necessary to combine the malignant degree, tumor stage, individual physique, accompanied by lymph node metastasis and organ metastasis, and usually focus on internal targeted therapy, commonly used drugs are imatinib, regorafenib, apatinib, etc., which can delay the aggravation of the disease and prolong the life cycle, but not a complete cure. Advanced gastrointestinal mesenchymal tumors, such as intestinal obstruction, intestinal perforation, severe bleeding, some patients still need to undergo surgery or other interventional methods, through a comprehensive means of treatment, can improve the quality of survival of patients, prolong the survival period, generally can not achieve a complete cure. Gastrointestinal mesenchymal tumors, once found, it is recommended to go to the relevant departments of the hospital in time and follow the doctor’s advice to choose the appropriate treatment plan.