Cold air allergy is a kind of allergic reaction disease. Oral antihistamines and glucocorticosteroids can be taken under the supervision of a doctor to alleviate the symptoms of allergy. Antihistamines are used to inhibit the allergic reaction caused by histamine by competing with histamine for histamine receptors. Cold air allergy patients can take loratadine, ebastine, etc., need to pay attention to the possibility of drowsiness, fatigue and other adverse reactions. Glucocorticoid is a kind of non-steroidal hormone, can inhibit the body’s immune response, serious patients can take oral prednisone, methylprednisone and so on. In addition, in the process of glucocorticoid use, there is a possibility of metabolic disorders, attention should be paid to regular monitoring of blood glucose, blood lipids and other indicators. If cold air allergy occurs, in daily life, pay attention to cold protection and warmth, and reduce outdoor activities in cold weather to prevent the occurrence of allergy. If it is difficult to relieve on their own, it is recommended to consult a doctor in a timely manner, under the guidance of the doctor for standardized treatment, do not self-medication.