Herpes simplex on buttocks can be treated with medications such as acyclovir under the guidance of a doctor, as well as rest and avoiding sexual intercourse. Herpes simplex is caused by the herpes simplex virus. Herpes simplex on the buttocks may be genital herpes, which is mostly seen in adults. It can be treated orally with acyclovir, famciclovir, vasiclovir and other medications under a doctor’s supervision, and commonly used topical medications also include acyclovir ointment, glycerite lotion and so on. If there is secondary infection, mupirocin ointment and fusidic acid cream can be used. In addition to this, you need to pay attention to rest and avoid sexual intercourse. It is recommended to go to the hospital for examination in time to identify the cause of the disease and use medication under the guidance of the doctor.