Cirrhosis with elevated alpha-fetoprotein should be diagnosed with the help of specialized doctors by completing liver enhancement CT, MRI and other examinations. After clarifying the severity of the disease, we will consider choosing the drug treatment for liver protection and liver care, surgical treatment, radiofrequency ablation treatment, targeted therapy and so on. 1. Drug treatment for liver protection and liver care: If cirrhosis is caused by liver damage, after self-repair and regeneration of liver, there will be the phenomenon of elevated alpha-fetoprotein, and you should actively cooperate with professional doctors to choose drugs for liver protection and liver care, such as silymarin capsule, diammonium glycyrrhizinate, compound glycyrrhizin, reduced glutathione and so on. 2. Surgery: If cirrhosis is combined with hepatocellular carcinoma, which leads to the elevation of alpha-fetoprotein, we should cooperate with professional doctors to carry out surgical resection treatment as soon as possible. 3. Radiofrequency ablation therapy: if cirrhosis is combined with liver cancer and the lesion is relatively small, radiofrequency ablation therapy can be adopted. 4. Targeted therapy: if cirrhosis combined with hepatocellular carcinoma has intrahepatic metastasis, recurrence or distant metastasis after surgery, targeted drugs can be used for treatment. If cirrhosis is accompanied by elevated alpha-fetoprotein, it is recommended to cooperate with professional doctors as soon as possible to improve the examination, to clarify the type of disease, and to adopt corresponding treatment plan in time, and do not self-medicate to avoid further aggravation of the condition.