Numbness in both hands is usually not the reason for taking exemestane tablets, numbness in both hands may be caused by thoracic outlet syndrome, peripheral neuritis, cervical disc herniation and so on. Exemestane tablets are used in the adjuvant treatment of breast cancer, is a kind of endocrine therapy drugs, the instructions did not mention that this drug can cause numbness of the limbs. 1. Thoracic outlet syndrome: refers to the thoracic outlet, due to some reasons lead to the brachial plexus nerve, subclavian artery and vein compression, mainly manifested as unilateral or bilateral shoulder, arm and hand pain, numbness, or even muscle atrophy and weakness, hand cold and purple, radial artery pulsation weakening, and so on. 2. Peripheral neuritis: peripheral nerves are affected by mechanical compression, nutritional disorders, metabolic disorders, infections, autoimmune diseases and other factors, peripheral neuritis will occur. Patients will have numbness in both hands, accompanied by tenderness, burning and other symptoms. 3. Cervical intervertebral disc herniation: If the patient works for a long time with his head down, exertion, etc., cervical intervertebral disc degeneration will occur, and there will be a fracture of the annulus fibrosus, the protruding intervertebral discs and nerve stimulation will produce inflammatory factors, such as involving the bilateral cervical nerve roots, which will cause numbness in both hands. It is recommended that patients go to the hospital in time, under the diagnosis of the doctor, according to the patient’s condition, targeted treatment.