Watery diarrhea with weight loss is not certain to be pancreatic cancer, watery diarrhea and weight loss are only the symptoms and clinical manifestations of the disease, it is difficult to determine the disease; generally consider acute gastroenteritis, bacterial dysentery, viral enteritis and other causes. 1. There are many causes of watery diarrhea with weight loss, most of them are seen in acute gastroenteritis (caused by unclean diet), bacterial dysentery (caused by dysentery bacillus infection), viral enteritis (caused by rotavirus infection), etc. The above mentioned diseases can cause this symptom, and weight loss can be caused by a large amount of diarrhea and loss of water in a short period of time. 2. Pancreatic cancer starts insidiously, and patients’ early clinical symptoms are atypical, which can be manifested as epigastric discomfort, low back pain, indigestion or diarrhea, etc. Once jaundice and emaciation appear, it is usually considered to be in advanced stage. Although pancreatic cancer may cause watery diarrhea with weight loss, the diagnosis cannot be confirmed by this symptom; it needs to be based on the symptoms (pain in middle and upper abdomen, jaundice, diarrhea, weight loss, etc.), signs (pressure pain in middle and upper abdomen, palpable mass, etc.), auxiliary examinations (ultrasound, CT, tumor markers, pathology, etc.) and other relevant examinations to further clarify the diagnosis. It is recommended to go to the hospital, complete the relevant examinations, and carry out targeted treatment after a clear diagnosis of the cause of the disease.