Bile vomiting in advanced stage of pancreatic cancer is usually related to digestive discomfort, which may be caused by tumor compression and infiltration of digestive tract, etc. Patients need to pay attention to it. Pancreatic cancer is a kind of malignant tumor originated from pancreatic ductal epithelium and alveolar cells, with high malignant degree, difficult early diagnosis and rapid progress. Its etiology is not yet clear, and it may be caused by precancerous lesions, genetic abnormalities, and hereditary factors. Early stage patients may experience symptoms such as epigastric discomfort, lower back pain, indigestion, and jaundice. When the disease develops, as pancreatic tumor may compress local intestinal tissues and cause abnormal drainage of bile in the intestine, patients may have symptoms such as vomiting of bile, abdominal pain, high fever, fatigue, and emaciation, etc. Some patients do not have pancreatic tumor compressing the digestive tract, which may be caused by genetic abnormalities. Some patients’ tumors do not compress the digestive tract, but they may have serious digestive symptoms, such as nausea, vomiting, etc. When patients do not have or have vomited the contents in stomach and duodenum, they may vomit bile. Patients with advanced pancreatic cancer need to actively cooperate with doctors to take relevant treatment measures so as not to delay the condition.