There is no definite conclusion on how many times chemotherapy for pancreatic cancer appears to be efficacious, specifically related to the progress of the disease, chemotherapy program and so on. Pancreatic cancer is a kind of digestive tract malignant tumor with insidious onset, rapid progression, extremely poor treatment effect and prognosis. For patients with pancreatic cancer combined with liver metastasis, aggressive chemotherapy can help relieve symptoms, improve quality of life and prolong survival. For those with better physical status, the preferred combination regimen is FOLFIRINOX, gemcitabine combined with albumin-binding paclitaxel or gemcitabine combined with tiglio, etc.; for those with poor physical status, they can choose gemcitabine or tiglio single-agent regimen. Gemcitabine in combination with molecular targeted therapy is also a viable option. The FOLFIRINOX regimen usually consists of 8 cycles (2 weeks for 1 cycle), with abdominal CT review after the 4th and 8th cycles to determine the follow-up treatment plan based on disease control. If pancreatic cancer is suspected or diagnosed, it is recommended to go to a regular hospital to evaluate the condition, follow the doctor’s instructions to cooperate with the treatment, and choose the appropriate program according to the situation to avoid delaying the condition. Please strictly follow the doctor’s instructions for medication, and do not use medication on your own.