There is no so-called best drug for the conservative treatment of osteonecrosis of the femoral head, and the drugs commonly used in the clinic are anti-inflammatory and analgesic drugs, anti-coagulant drugs, anti-osteoporosis drugs, lipid-lowering drugs and so on. 1. Anti-inflammatory and analgesic drugs: usually choose non-steroidal drugs, such as celecoxib, diclofenac sodium, meloxicam and so on, which play the role of anti-inflammatory and pain relief. 2. Anticoagulant drugs: such as low molecular heparin sodium, prostaglandin, etc., can significantly improve the hypercoagulable state of the blood, accelerate the fibrinolysis, improve microcirculation and local blood supply, which can help the treatment of femoral head necrosis. 3. Anti-osteoporosis drugs: bisphosphonates can be chosen, such as alendronate, diphosphonates, etc., which can inhibit the activity of osteoclasts, increase the amount of bone and slow down the destruction and resorption of bone. 4. Lipid-lowering drugs: such as atorvastatin, pravastatin, etc., which can promote osteogenesis and improve the blood supply of femoral head. The drug treatment of osteonecrosis of the femoral head can generally relieve clinical symptoms and slow down the progress of the disease. If a complete cure is needed, surgical treatment may be required, and it is recommended to consult a specialist for standardized treatment. The above medication should be used in accordance with medical advice to avoid adverse effects.