Portal vein trunk width of 1.6 centimeters may be caused by portal hypertension. Patients need to identify the primary cause of portal hypertension and then undergo targeted treatment. The inner diameter of the portal vein is within 1 cm in normal people, and in some normal people, the inner diameter of the portal vein can be up to 1.2 cm. If the width of the portal vein trunk is 1.6 centimeters, then widening of the portal vein is considered. In most patients, the increase in portal vein diameter is related to portal hypertension, which can be caused by cirrhosis, hepatocellular carcinoma and other diseases. Patients need to actively treat the primary disease, such as viral hepatitis patients actively using entecavir, sofosbuvir and other antiviral therapy; alcoholic liver disease patients actively quit drinking; immune liver disease patients using glucocorticoids and other therapies. In early stage patients, treatment of primary disease can be taken under the guidance of the doctor at the same time the pituitary posterior lobe hormone, carvedilol and other drugs to reduce portal blood flow to reduce the pressure. If the cirrhosis portal hypertension progresses to the decompensated stage, it is necessary to reduce the pressure of the portal vein through the operation of cut-off and shunt, etc., and the serious patients can be treated by liver transplantation. Portal vein trunk width of 1.6cm is often more serious, patients should pay attention to it, and actively cooperate with doctors to check and treat.