48 years old does not come to menstruation coffee-colored discharge may be pregnancy, endocrine disorders, gynecological diseases and other reasons. 1. pregnancy: 48-year-old women usually have sex, menstruation does not come to consider pregnancy, coffee-colored discharge may be pregnant after the aura of miscarriage, may be the gestational sacs of unstable, poor embryonic development, the body of the progesterone is insufficient and so on the reasons for this, through the examination to determine whether the pregnancy, and then to determine whether the aura of miscarriage, and then to see whether to preserve the baby treatment. 2. Endocrine disorders: the gradual decline of ovarian function in 48-year-old women may lead to the imbalance of estrogen and progesterone levels in the body, resulting in the phenomenon of irregular menstruation accompanied by coffee-colored discharge, go to the hospital to draw blood to check the hormone six, and then according to the individual situation with estrogen or progesterone medication to regulate, such as estradiol valerate, progesterone. 3. Gynecological diseases: 48-year-old women suffering from gynecological diseases, such as vaginitis, cervicitis, inflammation stimulates mucosal congestion and edema, may show coffee-colored secretions, to go to the hospital to do the routine examination of the leukorrhea, and then according to the inflammation of the symptomatic medication. The 48-year-old woman does not menstruate coffee-colored discharge causes more, it is recommended to timely medical treatment.