Glomerular filtration rate of 65ml/min is abnormal and below the lower limit of normal value. Glomerular filtration rate is an indicator reflecting the filtration function of the kidney, the normal glomerular filtration rate is 80~120ml/min, 65ml/min is lower than the lower limit of normal value, which belongs to the decrease of glomerular filtration rate. Usually the causes of glomerular filtration rate decrease are mainly acute kidney injury, primary glomerulonephritis, secondary glomerulonephritis, urinary tract tumor, etc.; or it may be a physiological decrease caused by aging. If the glomerular filtration rate continues to decline, it is recommended to consult the nephrology department of the hospital, improve the urine routine, renal function, related antibodies and other tests to clarify the cause of the disease and then carry out the treatment.