Liver metastasis of colon cancer is different from that of liver cancer, which is mainly manifested in the following aspects: pathogenesis, clinical manifestation, examination results, treatment, etc. 1. Pathogenesis: liver metastasis of colon cancer is mainly formed when the primary tumor metastasizes to the liver through bloodstream; liver cancer is cancerous transformation of liver cells. 2. Clinical manifestations: liver metastasis of colon cancer is mainly characterized by colon function and discomfort in liver area, but it is not the first symptom; liver cancer directly manifests as pain and discomfort in liver area and abnormal digestive system. 3. Examination results: liver metastasis of colon cancer mainly manifests as ring-shaped intensified nodules in liver, and alpha-fetoprotein may be normal, and pathological results are consistent with the primary tumor; liver cancer mainly manifests as significantly intensified mass in arterial phase, and alpha-fetoprotein rises, and pathological results are the primary tumor in liver. 4. Different treatments: the treatment of liver cancer is mainly surgical treatment, interventional therapy, etc., and comprehensive treatment (targeted therapy, radiotherapy, etc.) is given in case of progression, metastasis, etc.; colon cancer combined with liver metastasis is mainly comprehensive treatment, which needs to be carried out on primary foci and metastatic foci. When occupying lesions in liver are found, it is necessary to go to regular hospitals in time to diagnose the specific conditions through comprehensive examination by clinicians, and then carry out standardized treatment to avoid misdiagnosis.