Glucuronolactone is mainly used for liver detoxification and protection of liver function, long-term use will increase the adverse drug reactions, resulting in renal impairment and so on. 1. Adverse drug reactions: Glucuronolactone will produce nausea, vomiting, dizziness, diarrhea and other discomforts, long-term use may aggravate the adverse drug reactions. 2. Renal impairment: Glucuronolactone is mainly metabolized by the kidneys, long-term use will aggravate the burden on the kidneys, promote renal metabolism, affect renal function, damage to renal cells, and in severe cases, cause renal failure. Although Glucuronolactone has the effect of detoxification and anti-rheumatism, it should be used under the guidance of a doctor to avoid self-determination of the dosage and duration of medication, and is not recommended for long-term use.