The tetanus skin test refers to the tetanus antitoxin skin test, and the claim that 9 out of 10 patients will develop an allergy is not scientifically valid. Whether the allergy and personal constitution, but also with the purity of the drug and process has a certain relationship, the majority of the population does not appear allergic. Tetanus antitoxin skin test allergy has a lot to do with personal constitution. Tetanus antitoxin injection first need to do a skin test, if there is no allergy, before injection, if there is a positive skin test, it is recommended to inject tetanus immunoglobulin, the price is relatively expensive, but also can prevent tetanus. Tetanus antitoxin is a heterologous protein, which is extracted from horse serum, so the human body may have an allergic reaction to it, or even anaphylactic shock, which can lead to coma and death in serious cases. However, the tetanus antitoxin used in the clinic is strictly processed and purified, and the chance of inducing an allergic reaction in patients is relatively low, so the positive rate of skin test is not very high. Some patients can be considered for desensitization injection even if the skin test is positive. When it is necessary to inject tetanus antitoxin, it is necessary to consult a regular medical institution and strictly conduct skin test before injection.