Thigh muscles and tendons stringing pain should promptly identify the cause of pain, according to the specific circumstances of the medication, generally can take non-steroidal anti-inflammatory painkillers. Thigh muscle and tendon string pain may be due to muscle strain, fascial inflammation or lumbar disc herniation, etc. Different diseases have different treatment modalities, in the case of clear cause of the active treatment of the primary disease, but also symptomatic treatment. For the symptoms of pain, non-steroidal anti-inflammatory drugs such as celecoxib and ibuprofen can be used, but patients with gastrointestinal diseases or allergies to the drug should stop using it. In case of muscle strain, rest should be taken in time, and drugs that activate blood circulation and remove blood stasis should be used, such as Shujinhuaixu Tablets and Sanqi Injury Capsules, etc. They are prohibited for pregnant and lactating women. For lumbar intervertebral disc herniation, drugs that nourish the nerves such as methylcobalamin can be used, and those who are allergic to methylcobalamin are prohibited. It is recommended that patients should consult a doctor in time to further find out the cause of pain, and carry out symptomatic treatment under the doctor’s advice. The above drugs should be avoided blindly self-use.