High thyroglobulin antibodies mean that an autoimmune thyroid disease may be present, etc. Consultation with your doctor is recommended. Thyroglobulin antibody, known as Tg-Ab, is a common autoantibody found in the serum of patients with autoimmune thyroid disease. It is of clinical value in the regression and treatment of thyroiditis, especially Hashimoto’s thyroiditis. Serum Tg-Ab is a specific indicator for the diagnosis of thyroid autoimmune diseases and can be strongly positive in patients with chronic thyroiditis and hyperthyroidism. Transient hypothyroidism occurs in patients with hyperthyroidism during treatment and is closely related to Tg-Ab. Tg-Ab can be used as a differential diagnosis for goiter, and a positive test is usually considered for chronic lymphocytic thyroiditis rather than goiter. It is recommended to go to the hospital when high thyroglobulin antibodies are present and ask the doctor to make a judgment.