The exact recovery time of the liver from a single intoxication varies according to the efficiency of alcohol metabolism in the body, and in most cases it takes 1 to 2 weeks to fully metabolize it. Drunkenness is the common name for acute alcoholic intoxication, and the pathways of metabolism in the body can include the liver and the skin. Most alcohol is metabolized by the liver, so intoxication can increase the burden on the liver to some extent. In addition, alcohol and metabolites such as acetaldehyde can cause changes in the proteins of liver cells, which may cause liver cells to produce new antigens and stimulate the body’s immune response and damage liver cells. In some people, the lack of the enzyme alcohol detoxification can slow down the metabolism of alcohol in the body. Others have a correspondingly shorter liver recovery time due to their ability to detoxify alcohol. However, prolonged drinking may lead to poorer and poorer recovery of the liver, which is not conducive to physical and mental health.