Itchy toddlers in the middle of the night may be caused by physiological factors, may also be caused by pathological factors, such as eczema, insect bite dermatitis and other diseases. 1. Physiological factors: common in the fall and winter seasons, especially in the cold winter in the north, the indoor air is too dry, coupled with a long time at night did not drink water, resulting in skin dehydration, dryness, the skin barrier function is reduced, may cause young children in the middle of the night all over the body itchy. 2. Pathologic factors: (1) eczema: may be related to immune factors, environmental factors, genetic factors, when eczema on the body of young children, it will lead to itching in the middle of the night, with obvious oozing after scratching, which will also affect the quality of sleep of young children. (2) insect bite dermatitis: especially in the hot summer, due to more mosquitoes, it is easy to cause young children in the middle of the night by mosquito bites, causing insect bite dermatitis, which may cause young children in the middle of the night all over the body itchy, but also may be accompanied by local skin pain, swelling and other symptoms. Itchy toddlers in the middle of the night may also be caused by other diseases, it is recommended that parents bring their children to the regular hospital to find and clarify the cause of the disease, under the guidance of the doctor to give targeted treatment.