In the clinic there is no tamsulosin and doxazosin mesylate which is better, the pharmacological effects of the two drugs have no special difference. 1. Tamsulosin: usually refers to tamsulosin hydrochloride extended-release capsules, has the effect of relieving the spasm of the bladder neck orifice, reducing the resistance of the posterior urethra, etc. It can be used to treat the discomfort of urinary obstruction caused by prostate hyperplasia. Long-term use of the drug may cause nausea, vomiting and other adverse reactions, if suffering from low blood pressure or renal insufficiency patients should be used under the guidance of a doctor, children are prohibited from using the drug. 2. Doxazosin mesylate: generally refers to doxazosin mesylate extended-release tablets, belongs to is a kind of alpha receptor blocker, has the effect of relaxing the vascular smooth muscle, lowering the peripheral vascular resistance and so on, on the prostate hyperplasia, hypertension and other diseases caused by the discomfort to a certain extent. Long-term use of such drugs may cause malaise, edema and other discomforts, and the use of the drug is prohibited for pregnant and lactating women. When using the above two drugs, they should be used under the guidance of a doctor to avoid blind use of drugs and discomfort.